Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT(2B) receptor in rodent large bowel physiology

BACKGROUND: 5-HT(2B) receptors are localized within the myenteric nervous system, but their functions on motor/sensory neurons are unclear. To explore the role of these receptors, we further characterized the 5-HT(2B) receptor antagonist RS-127445 and studied its effects on peristalsis and defecatio...

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Detalhes bibliográficos
Main Authors: Bassil, AK, Taylor, CM, Bolton, VJN, Gray, KM, Brown, JD, Cutler, L, Summerfield, SG, Bruton, G, Winchester, WJ, Lee, K, Sanger, GJ
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795249/
https://ncbi.nlm.nih.gov/pubmed/19371340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00155.x
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