An investigation into the structural determinants of cannabinoid receptor ligand efficacy

1. A number of side-chain analogues of Δ(8)-THC were tested in GTPγS binding assay in rat cerebellar membranes. O-1125, a saturated side-chain compound stimulated GTPγS binding with an E(max) of 165.0%, and an EC(50) of 17.4 nM. 2. O-1236, O-1237 and O-1238, three-enyl derivatives containing a cis c...

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Detalhes bibliográficos
Main Authors: Griffin, Graeme, Wray, Emma J, Rorrer, William K, Crocker, Peter J, Ryan, William J, Saha, Bijali, Razdan, Raj K, Martin, Billy R, Abood, Mary E
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565939/
https://ncbi.nlm.nih.gov/pubmed/10323589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702469
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