Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

1. Bioactivation of sulphamethoxazole (SMX) to chemically-reactive metabolites and subsequent protein conjugation is thought to be involved in SMX hypersensitivity. We have therefore examined the cellular metabolism, disposition and conjugation of SMX and its metabolites in vitro. 2. Flow cytometry...

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Main Authors: Naisbitt, Dean J, Hough, Sally J, Gill, Helen J, Pirmohamed, Munir, Kitteringham, Neil R, Park, B Kevin
Formato: Artigo
Idioma:Inglês
Publicado: 1999
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Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565922/
https://ncbi.nlm.nih.gov/pubmed/10217534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702453
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