Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages

1. Activation of macrophages with lipopolysaccharide (LPS) and low doses of interferon-γ (IFN-γ) induced apoptotic death through a nitric oxide-dependent pathway. 2. Treatment of cells with the immunosuppressors cyclosporin A (CsA) or FK506 inhibited the activation-dependent apoptosis. 3. These drug...

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Bibliographic Details
Main Authors: Hortelano, Sonsoles, López-Collazo, Eduardo, Boscá, Lisardo
Format: Artigo
Language:Inglês
Published: 1999
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565893/
https://ncbi.nlm.nih.gov/pubmed/10205001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702422
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