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Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

Immunosuppressants FK506 and cyclosporin A inhibit neurotoxicity of N-methyl-D-aspartate in primary cortical cultures, while having no effect on quisqualate- and kainate-mediated neurotoxicity. Rapamycin completely reverses the neuroprotective effect of FK506. Both FK506 and cyclosporin A inhibit NM...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Dawson, T M, Steiner, J P, Dawson, V L, Dinerman, J L, Uhl, G R, Snyder, S H
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47661/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7694293/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.21.9808
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