Modulation of IL-1-induced cartilage injury by NO synthase inhibitors: a comparative study with rat chondrocytes and cartilage entities

1. Nitric oxide (NO) is produced in diseased joints and may be a key mediator of IL-1 effects on cartilage. Therefore, we compared the potency of new [aminoguanidine (AG), S-methylisothiourea (SMT), S-aminoethylisothiourea (AETU)] and classical [N(ω)-monomethyl-L-arginine (L-NMMA), N(ω)-nitro-L-argi...

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Detalhes bibliográficos
Main Authors: Cipolletta, Christine, Jouzeau, Jean-Yves, Gegout-Pottie, Pascale, Presle, Nathalie, Bordji, Karim, Netter, Patrick, Terlain, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565565/
https://ncbi.nlm.nih.gov/pubmed/9756389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702005
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