Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action

1. The class III antiarrhythmic azimilide has previously been shown to inhibit I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. Because HERG channels underly the conductance I(Kr) in human heart, the effects of azimilide on HERG channels expresse...

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Detalhes bibliográficos
Main Authors: Busch, A E, Eigenberger, B, Jurkiewicz, N K, Salata, J J, Pica, A, Suessbrich, H, Lang, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1998
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Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565134/
https://ncbi.nlm.nih.gov/pubmed/9484850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701575
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