PNU-107484A with α isoform-dependent functional changes in αxβ2γ2 subtypes of rat recombinant GABA(A) receptors

1. We discovered a novel γ-aminobutyric acid(A) (GABA(A)) receptor ligand displaying seemingly opposite functionalities, depending on the α isoform of the αxβ2γ2 subtypes. PNU-107484A enhanced GABA-induced Cl(−) currents in the α1β2γ2 subtype, but inhibited the currents in the α3β2γ2 and α6β2γ2 subt...

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Bibliografische gegevens
Hoofdauteurs: Im, Haesook K, Im, Wha Bin, Carter, Donald B, Schwartz, Theresa M, Bundy, Gordon L, Von Voigtlander, Philip F
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1997
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Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565006/
https://ncbi.nlm.nih.gov/pubmed/9384496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701450
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