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Effect of copper on nitric oxide synthase and guanylyl cyclase activity in the rat isolated aorta

1. The potential role of copper (Cu(2+)) in modulating the activity of nitric oxide synthase (NOS) and guanylyl cyclase (GC) was investigated by use of diethyldithiocarbamic acid (DEDCA), a high affinity Cu(2+) chelator. 2. DEDCA 100 μM inhibited sodium nitroprusside (SNP; 0.005–10 μM)-evoked relaxa...

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Main Authors: Plane, Frances, Wigmore, Sarah, Angelini, Gianni D, Jeremy, Jamie Y
Formato: Artigo
Idioma:Inglês
Publicado: 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564688/
https://ncbi.nlm.nih.gov/pubmed/9154347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701144
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