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Effects of phosphodiesterase inhibitors on human lung mast cell and basophil function

1. The non-hydrolysable cyclic AMP analogue, dibutyryl (Bu(2))-cyclic AMP, inhibited the stimulated release of histamine from both basophils and human lung mast cells (HLMC) in a dose-dependent manner. The concentrations required to inhibit histamine release by 50% (IC(50)) were 0.8 and 0.7 mM in ba...

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Detalhes bibliográficos
Main Authors: Weston, Marie C, Anderson, Nicola, Peachell, Peter T
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564674/
https://ncbi.nlm.nih.gov/pubmed/9154339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701115
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