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Role of calcineurin in the regulation of human lung mast cell and basophil function by cyclosporine and FK506
BACKGROUND AND PURPOSE: Cyclosporine and FK506 are thought to act by targeting the Ca(2+)-dependent protein phosphatase, calcineurin. The aim of the present study was to determine whether cyclosporine and FK506 stabilize mast cells and basophils by interacting with calcineurin. EXPERIMENTAL APPROACH...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2189730/ https://ncbi.nlm.nih.gov/pubmed/17200674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707002 |
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