Role of calcineurin in the regulation of human lung mast cell and basophil function by cyclosporine and FK506

BACKGROUND AND PURPOSE: Cyclosporine and FK506 are thought to act by targeting the Ca(2+)-dependent protein phosphatase, calcineurin. The aim of the present study was to determine whether cyclosporine and FK506 stabilize mast cells and basophils by interacting with calcineurin. EXPERIMENTAL APPROACH...

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Bibliografske podrobnosti
Main Authors: Harrison, C A, Bastan, R, Peirce, M J, Munday, M R, Peachell, P T
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2007
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2189730/
https://ncbi.nlm.nih.gov/pubmed/17200674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707002
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