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Dissociation of lipopolysaccharide-mediated induction of nitric oxide synthase and inhibition of DNA synthesis in RAW 264.7 macrophages and rat aortic smooth muscle cells

1. The active component of endotoxin, lipopolysaccharide (LPS), inhibited basal DNA synthesis in both RAW 264.7 macrophages (IC(50) 0.05±0.03 μg ml(−1)) and rat aortic smooth muscle cells (RASMC) (IC(50) 9.7±0.4 μg ml(−1)). 2. In both cell types, serum differentially affected LPS-stimulated inhibiti...

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Autors principals: Paul, Andrew, Bryant, Clare, Lawson, Mark F, Chilvers, Edwin R, Plevin, Robin
Format: Artigo
Idioma:Inglês
Publicat: 1997
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564627/
https://ncbi.nlm.nih.gov/pubmed/9113363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701070
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