Dissociation of lipopolysaccharide-mediated induction of nitric oxide synthase and inhibition of DNA synthesis in RAW 264.7 macrophages and rat aortic smooth muscle cells

1. The active component of endotoxin, lipopolysaccharide (LPS), inhibited basal DNA synthesis in both RAW 264.7 macrophages (IC(50) 0.05±0.03 μg ml(−1)) and rat aortic smooth muscle cells (RASMC) (IC(50) 9.7±0.4 μg ml(−1)). 2. In both cell types, serum differentially affected LPS-stimulated inhibiti...

Full description

Saved in:
Bibliographic Details
Main Authors: Paul, Andrew, Bryant, Clare, Lawson, Mark F, Chilvers, Edwin R, Plevin, Robin
Format: Artigo
Language:Inglês
Published: 1997
Subjects:
Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564627/
https://ncbi.nlm.nih.gov/pubmed/9113363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701070
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items