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Inhibition of the constitutive activity of human 5-HT(1A) receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635

At recombinant human 5-hydroxytryptamine (5-HT)5-HT(1A) receptors expressed in Chinese hamster ovary cells (CHO-5-HT(1A)), 5-carboxamidotryptamine (5-CT), acted as a full agonist (relative to 5-HT=100%) for stimulation of receptor-mediated [(35)S]-GTPγS (guanylyl 5′-[γ-thio]-tryphosphate) binding. I...

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Detaylı Bibliyografya
Asıl Yazarlar: Newman-Tancredi, Adrian, Conte, Caroline, Chaput, Christine, Spedding, Michael, Millan, Mark J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1997
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564555/
https://ncbi.nlm.nih.gov/pubmed/9138675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701025
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