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NikR–operator complex structure and the mechanism of repressor activation by metal ions

Metal ion homeostasis is critical to the survival of all cells. Regulation of nickel concentrations in Escherichia coli is mediated by the NikR repressor via nickel-induced transcriptional repression of the nickel ABC-type transporter, NikABCDE. Here, we report two crystal structures of nickel-activ...

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Main Authors: Schreiter, Eric R., Wang, Sheila C., Zamble, Deborah B., Drennan, Catherine L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564233/
https://ncbi.nlm.nih.gov/pubmed/16945905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606247103
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