Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA

Whereas evolutionary inferences derived from present-day DNA sequences are by necessity indirect, ancient DNA sequences provide a direct view of past genetic variants. However, base lesions that accumulate in DNA over time may cause nucleotide misincorporations when ancient DNA sequences are replica...

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Hlavní autoři: Stiller, M., Green, R. E., Ronan, M., Simons, J. F., Du, L., He, W., Egholm, M., Rothberg, J. M., Keates, S. G., Ovodov, N. D., Antipina, E. E., Baryshnikov, G. F., Kuzmin, Y. V., Vasilevski, A. A., Wuenschell, G. E., Termini, J., Hofreiter, M., Jaenicke-Després, V., Pääbo, S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564221/
https://ncbi.nlm.nih.gov/pubmed/16938852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605327103
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