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Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA
Whereas evolutionary inferences derived from present-day DNA sequences are by necessity indirect, ancient DNA sequences provide a direct view of past genetic variants. However, base lesions that accumulate in DNA over time may cause nucleotide misincorporations when ancient DNA sequences are replica...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1564221/ https://ncbi.nlm.nih.gov/pubmed/16938852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605327103 |
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