Altered Gag Polyprotein Cleavage Specificity of Feline Immunodeficiency Virus/Human Immunodeficiency Virus Mutant Proteases as Demonstrated in a Cell-Based Expression System

We have used feline immunodeficiency virus (FIV) protease (PR) as a mutational system to study the molecular basis of substrate-inhibitor specificity for lentivirus PRs, with a focus on human immunodeficiency virus type 1 (HIV-1) PR. Our previous mutagenesis studies demonstrated that discrete substi...

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Detalhes bibliográficos
Main Authors: Lin, Ying-Chuan, Brik, Ashraf, de Parseval, Aymeric, Tam, Karen, Torbett, Bruce E., Wong, Chi-Huey, Elder, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563824/
https://ncbi.nlm.nih.gov/pubmed/16873240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00374-06
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