Surface Mutagenesis of the Bovine Papillomavirus E1 DNA Binding Domain Reveals Residues Required for Multiple Functions Related to DNA Replication

The E1 protein from papillomaviruses is a multifunctional protein with complex functions required for the initiation of viral DNA replication. We have performed a surface mutagenesis of the well-characterized E1 DNA binding domain (DBD). We demonstrate that substitutions of multiple residues on the...

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Bibliographic Details
Main Authors: Schuck, Stephen, Stenlund, Arne
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563737/
https://ncbi.nlm.nih.gov/pubmed/16840329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00435-06
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