Intracellular Penetration and Activity of DX-619 in Human Polymorphonuclear Leukocytes

The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 reached intracellular concentrations 10 times higher than the extracellular concentrations reached. Uptake was rapid, reversible, nonsaturable, and affected by environmental tempera...

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Bibliografiske detaljer
Main Authors: García, Isabel, Ballesta, Sofía, Murillo, Concepción, Perea, Evelio J., Pascual, Álvaro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563540/
https://ncbi.nlm.nih.gov/pubmed/16940122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00427-06
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