Global DNA hypermethylation-associated cancer chemotherapy resistance and its reversion with the demethylating agent hydralazine

BACKGROUND: The development of resistance to cytotoxic chemotherapy continues to be a major obstacle for successful anticancer therapy. It has been shown that cells exposed to toxic concentrations of commonly used cancer chemotherapy agents develop DNA hypermetylation. Hence, demethylating agents co...

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Main Authors: Segura-Pacheco, Blanca, Perez-Cardenas, Enrique, Taja-Chayeb, Lucia, Chavez-Blanco, Alma, Revilla-Vazquez, Alma, Benitez-Bribiesca, Luis, Duenas-González, Alfonso
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2006
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563479/
https://ncbi.nlm.nih.gov/pubmed/16893460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-4-32
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