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Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
Amyloid-β peptide (Aβ) accumulation in the brain is an early, toxic event in the pathogenesis of Alzheimer's disease (AD). Aβ is produced by proteolytic processing of a transmembrane protein, β-amyloid precursor protein (APP), by β- and γ-secretases. Mounting evidence has demonstrated that alte...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BioMed Central
2006
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1563464/ https://ncbi.nlm.nih.gov/pubmed/16930455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-1-8 |
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