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Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility

As the central component of the human endotoxin sensor, Toll-like receptor 4 (TLR4) functions in the early detection and response to Gram-negative infection. We therefore examined a large collection of patients with meningococcal sepsis, comparing the frequency of rare TLR4 coding changes to those i...

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Detalhes bibliográficos
Main Authors: Smirnova, Irina, Mann, Navjiwan, Dols, Annemiek, Derkx, H. H., Hibberd, Martin L., Levin, Michael, Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC156328/
https://ncbi.nlm.nih.gov/pubmed/12730365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1031605100
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