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Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
As the central component of the human endotoxin sensor, Toll-like receptor 4 (TLR4) functions in the early detection and response to Gram-negative infection. We therefore examined a large collection of patients with meningococcal sepsis, comparing the frequency of rare TLR4 coding changes to those i...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The National Academy of Sciences
2003
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC156328/ https://ncbi.nlm.nih.gov/pubmed/12730365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1031605100 |
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