Hydrogen-exchange stability analysis of Bergerac-Src homology 3 variants allows the characterization of a folding intermediate in equilibrium
Amide hydrogen/deuterium exchange rates have been determined for two mutants of α-spectrin Src homology 3 domain (WT), containing an elongated stable (SHH) and unstable (SHA) distal loop. SHA, similarly to WT, follows a two-state transition, whereas SHH apparently folds via a three-state mechanism....
Sparad:
| I publikationen: | Proc Natl Acad Sci U S A |
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| Huvudupphov: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
National Academy of Sciences
2003
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156269/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12719536/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0837456100 |
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