Follicular Dendritic Cell Dedifferentiation by Treatment with an Inhibitor of the Lymphotoxin Pathway Dramatically Reduces Scrapie Susceptibility

Transmissible spongiform encephalopathies (TSEs) may be acquired peripherally, in which case infectivity usually accumulates in lymphoid tissues before dissemination to the nervous system. Studies of mouse scrapie models have shown that mature follicular dendritic cells (FDCs), expressing the host p...

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Bibliographische Detailangaben
Hauptverfasser: Mabbott, Neil A., Young, Janice, McConnell, Irene, Bruce, Moira E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC156207/
https://ncbi.nlm.nih.gov/pubmed/12768004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.12.6845-6854.2003
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