Mice deficient in α-actinin-4 have severe glomerular disease

Dominantly inherited mutations in ACTN4, which encodes α-actinin-4, cause a form of human focal and segmental glomerulosclerosis (FSGS). By homologous recombination in ES cells, we developed a mouse model deficient in Actn4. Mice homozygous for the targeted allele have no detectable α-actinin-4 prot...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kos, Claudine H., Le, Tu Cam, Sinha, Sumita, Henderson, Joel M., Kim, Sung Han, Sugimoto, Hikaru, Kalluri, Raghu, Gerszten, Robert E., Pollak, Martin R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC156110/
https://ncbi.nlm.nih.gov/pubmed/12782671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317988
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados