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Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids

It has been found that 4-estren-3α,17β-diol, a synthetic ligand for the estrogen receptor (ER) or androgen receptor (AR), which does not affect classical transcription, reverses bone loss in ovariectomized females or orchidectomized males without affecting the uterus or seminal vesicles, demonstrati...

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Autores principales: Kousteni, Stavroula, Han, Li, Chen, Jin-Ran, Almeida, Maria, Plotkin, Lilian I., Bellido, Teresita, Manolagas, Stavros C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2003
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC156107/
https://ncbi.nlm.nih.gov/pubmed/12782668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317261
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