Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation

Ras promotes the accumulation of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1) (p21). Previous studies reported that acute Raf/MEK/ERK activation elevates p21 protein levels by increased transcription. However, we have found that p21 induction in Ras-transformed murine fibroblasts occurs prin...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	EMBO J
Päätekijät:	Coleman, Mathew L., Marshall, Christopher J., Olson, Michael F.
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Publishing Group 2003
Aiheet:	Articles
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156064/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12727871/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg189
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!