Cytoplasmic p21(WAF1/CIP1 )expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis

BACKGROUND: HER-2 (c-erbB2/Neu) predicts the prognosis of and may influence treatment responses in breast cancer. HER-2 activity induces the cytoplasmic location of p21(WAFI/CIPI )in cell culture, accompanied by resistance to apoptosis. p21(WAFI/CIPI )is a cyclin-dependent kinase inhibitor activated...

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Detalhes bibliográficos

Publicado no:	Breast Cancer Res
Principais autores:	Winters, Zoë E, Leek, Russell D, Bradburn, Mike J, Norbury, Chris J, Harris, Adrian L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2003
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314414/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14580260/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/bcr654
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