Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation

Ras promotes the accumulation of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1) (p21). Previous studies reported that acute Raf/MEK/ERK activation elevates p21 protein levels by increased transcription. However, we have found that p21 induction in Ras-transformed murine fibroblasts occurs prin...

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Pubblicato in:	EMBO J
Autori principali:	Coleman, Mathew L., Marshall, Christopher J., Olson, Michael F.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2003
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156064/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12727871/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg189
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