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Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor

The transformation potential of Simian Virus 40 depends on the activities of large T-antigen (LTag), which interacts with several cellular tumor suppressors including the important “guardian” of the genome, p53. Inhibition of p53 function by LTag is necessary for both efficient viral replication and...

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書誌詳細
主要な著者: Lilyestrom, Wayne, Klein, Michael G., Zhang, Rongguang, Joachimiak, Andrzej, Chen, Xiaojiang S.
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1560412/
https://ncbi.nlm.nih.gov/pubmed/16951253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1456306
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