Solution structure of the ActD–5′-CCGTT(3)GTGG-3′ complex: drug interaction with tandem G·T mismatches and hairpin loop backbone
Binding of actinomycin D (ActD) to the seemingly single-stranded DNA (ssDNA) oligomer 5′-CCGTT(3) GTGG-3′ has been studied in solution using high-resolution nuclear magnetic resonance (NMR) techniques. A strong binding constant (8 × 10(6) M(–1)) and high quality NMR spectra have allowed us to determ...
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| Publicado no: | Nucleic Acids Res |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156035/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12736312/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg353 |
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