Solution structure of the ActD–5′-CCGTT(3)GTGG-3′ complex: drug interaction with tandem G·T mismatches and hairpin loop backbone

Binding of actinomycin D (ActD) to the seemingly single-stranded DNA (ssDNA) oligomer 5′-CCGTT(3) GTGG-3′ has been studied in solution using high-resolution nuclear magnetic resonance (NMR) techniques. A strong binding constant (8 × 10(6) M(–1)) and high quality NMR spectra have allowed us to determ...

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Publicado en:	Nucleic Acids Res
Autores principales:	Chin, Ko-Hsin, Chen, Fu-Ming, Chou, Shan-Ho
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 2003
Materias:	Articles
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156035/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12736312/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg353
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