Signaling, Polyubiquitination, Trafficking, and Inclusions: Sequestosome 1/p62's Role in Neurodegenerative Disease

Aggregated misfolded proteins are hallmarks of most neurodegenerative diseases. In a chronic disease state, including pathologic situations of oxidative stress, these proteins are sequestered into inclusions. Accumulation of aggregated proteins can be prevented by chaperones, or by targeting their d...

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Autores principales: Wooten, Marie W., Hu, Xiao, Babu, J. Ramesh, Seibenhener, M. Lamar, Geetha, Thangiah, Paine, Michael G., Wooten, Michael C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2006
Materias:
Review Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1559922/
https://ncbi.nlm.nih.gov/pubmed/17047309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/JBB/2006/62079
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