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Opposing functions of ZEB proteins in the regulation of the TGFβ/BMP signaling pathway
Binding of TGFβ/BMP factors to their receptors leads to translocation of Smad proteins to the nucleus where they activate transcription of target genes. The two-handed zinc finger proteins encoded by Zfhx1a and Zfhx1b, ZEB-1/δEF1 and ZEB-2/SIP1, respectively, regulate gene expression and differentia...
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2003
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC155983/ https://ncbi.nlm.nih.gov/pubmed/12743038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg225 |
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