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Transcriptional potential of the γ-globin gene is dependent on the CACCC box in a developmental stage-specific manner
To test the role of CACCC box on γ-globin gene activation, the CACCC box was deleted or mutated and γ-gene expression was monitored in transgenic mice. Disruption of the CACCC box had no effect on γ-gene expression in the cells of embryonic erythropoiesis but it strikingly reduced γ-gene expression...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1557803/ https://ncbi.nlm.nih.gov/pubmed/16914453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl474 |
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