Mutational Analysis of the Enzymatic Domain of Clostridium difficile Toxin B Reveals Novel Inhibitors of the Wild-Type Toxin

Toxin B (TcdB), a major Clostridium difficile virulence factor, glucosylates and inactivates the small GTP-binding proteins Rho, Rac, and Cdc42. In the present study we provide evidence that enzymatically inactive fragments of the TcdB enzymatic domain are effective intracellular inhibitors of nativ...

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Bibliographic Details
Main Authors: Spyres, Lea M., Daniel, Jeremy, Hensley, Amy, Qa'Dan, Maen, Ortiz-Leduc, William, Ballard, Jimmy D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC155706/
https://ncbi.nlm.nih.gov/pubmed/12761111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.6.3294-3301.2003
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