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Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

The larger isoform of the enzyme glutamate decarboxylase, GAD67, synthesizes >90% of basal levels of γ-aminobutyric acid (GABA) in the brain. In contrast, the smaller isoform, GAD65, has been implicated in the fine-tuning of inhibitory neurotransmission. Mice deficient in GAD65 exhibit increased...

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Détails bibliographiques
Auteurs principaux: Kash, Shera F., Tecott, Laurence H., Hodge, Clyde, Baekkeskov, Steinunn
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 1999
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC15565/
https://ncbi.nlm.nih.gov/pubmed/9990087
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