Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase
The larger isoform of the enzyme glutamate decarboxylase, GAD67, synthesizes >90% of basal levels of γ-aminobutyric acid (GABA) in the brain. In contrast, the smaller isoform, GAD65, has been implicated in the fine-tuning of inhibitory neurotransmission. Mice deficient in GAD65 exhibit increased anx...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15565/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9990087/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.4.1698 |
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