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Nuclear Localization of PTEN by a Ran-dependent Mechanism Enhances Apoptosis: Involvement of an N-Terminal Nuclear Localization Domain and Multiple Nuclear Exclusion Motifs

The targeting of the tumor suppressor PTEN protein to distinct subcellular compartments is a major regulatory mechanism of PTEN function, by controlling its access to substrates and effector proteins. Here, we investigated the molecular basis and functional consequences of PTEN nuclear/cytoplasmic d...

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Main Authors: Gil, Anabel, Andrés-Pons, Amparo, Fernández, Elena, Valiente, Miguel, Torres, Josema, Cervera, Javier, Pulido, Rafael
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Cell Biology 2006
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1556382/
https://ncbi.nlm.nih.gov/pubmed/16807353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-05-0380
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