Expression of Human PTEN-L in a Yeast Heterologous Model Unveils Specific N-Terminal Motifs Controlling PTEN-L Subcellular Localization and Function

The tumour suppressor PTEN is frequently downregulated, mutated or lost in several types of tumours and congenital disorders including PHTS (PTEN Hamartoma Tumour Syndrome) and ASD (Autism Spectrum Disorder). PTEN is a lipid phosphatase whose activity over the lipid messenger PIP(3) counteracts the...

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Xehetasun bibliografikoak
Argitaratua izan da:Cells
Egile Nagusiak: Fernández-Acero, Teresa, Bertalmio, Eleonora, Luna, Sandra, Mingo, Janire, Bravo-Plaza, Ignacio, Rodríguez-Escudero, Isabel, Molina, María, Pulido, Rafael, Cid, Víctor J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952770/
https://ncbi.nlm.nih.gov/pubmed/31779149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8121512
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