Expression of Human PTEN-L in a Yeast Heterologous Model Unveils Specific N-Terminal Motifs Controlling PTEN-L Subcellular Localization and Function

The tumour suppressor PTEN is frequently downregulated, mutated or lost in several types of tumours and congenital disorders including PHTS (PTEN Hamartoma Tumour Syndrome) and ASD (Autism Spectrum Disorder). PTEN is a lipid phosphatase whose activity over the lipid messenger PIP(3) counteracts the...

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Publicado no:Cells
Main Authors: Fernández-Acero, Teresa, Bertalmio, Eleonora, Luna, Sandra, Mingo, Janire, Bravo-Plaza, Ignacio, Rodríguez-Escudero, Isabel, Molina, María, Pulido, Rafael, Cid, Víctor J.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952770/
https://ncbi.nlm.nih.gov/pubmed/31779149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8121512
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