Error-Prone Polymerase, DNA Polymerase IV, Is Responsible for Transient Hypermutation during Adaptive Mutation in Escherichia coli

The frequencies of nonselected mutations among adaptive Lac(+) revertants of Escherichia coli strains with and without the error-prone DNA polymerase IV (Pol IV) were compared. This frequency was more than sevenfold lower in the Pol IV-defective strain than in the wild-type strain. Thus, the mutatio...

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Main Authors: Tompkins, Joshua D., Nelson, Jennifer L., Hazel, Jill C., Leugers, Stacy L., Stumpf, Jeffrey D., Foster, Patricia L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Genetics and Molecular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC155394/
https://ncbi.nlm.nih.gov/pubmed/12754247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.11.3469-3472.2003
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