Error-Prone Polymerase, DNA Polymerase IV, Is Responsible for Transient Hypermutation during Adaptive Mutation in Escherichia coli

The frequencies of nonselected mutations among adaptive Lac(+) revertants of Escherichia coli strains with and without the error-prone DNA polymerase IV (Pol IV) were compared. This frequency was more than sevenfold lower in the Pol IV-defective strain than in the wild-type strain. Thus, the mutatio...

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Publié dans:	J Bacteriol
Auteurs principaux:	Tompkins, Joshua D., Nelson, Jennifer L., Hazel, Jill C., Leugers, Stacy L., Stumpf, Jeffrey D., Foster, Patricia L.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2003
Sujets:	Genetics and Molecular Biology
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155394/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12754247/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.185.11.3469-3472.2003
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