p27(Kip1) Inhibition of GRB2-SOS Formation Can Regulate Ras Activation

p27(Kip1) (p27) is often inappropriately downregulated in aggressive human cancers. Although p27 can inhibit cyclin-dependent kinases (CDKs), low p27 does not always correlate with increased CDK activity. Furthermore, cells derived from p27(−/−) mice respond to antimitogens, maintain restriction poi...

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Bibliografski detalji
Glavni autori: Moeller, Stephanie J., Head, Elizabeth D., Sheaff, Robert J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Cell Growth and Development
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC155227/
https://ncbi.nlm.nih.gov/pubmed/12748278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.11.3735-3752.2003
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