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p27(Kip1) Inhibition of GRB2-SOS Formation Can Regulate Ras Activation
p27(Kip1) (p27) is often inappropriately downregulated in aggressive human cancers. Although p27 can inhibit cyclin-dependent kinases (CDKs), low p27 does not always correlate with increased CDK activity. Furthermore, cells derived from p27(−/−) mice respond to antimitogens, maintain restriction poi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC155227/ https://ncbi.nlm.nih.gov/pubmed/12748278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.11.3735-3752.2003 |
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