p27(Kip1) Inhibition of GRB2-SOS Formation Can Regulate Ras Activation

p27(Kip1) (p27) is often inappropriately downregulated in aggressive human cancers. Although p27 can inhibit cyclin-dependent kinases (CDKs), low p27 does not always correlate with increased CDK activity. Furthermore, cells derived from p27(−/−) mice respond to antimitogens, maintain restriction poi...

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Publicado en:	Mol Cell Biol
Autores principales:	Moeller, Stephanie J., Head, Elizabeth D., Sheaff, Robert J.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2003
Materias:	Cell Growth and Development
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155227/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12748278/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.11.3735-3752.2003
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