Reduced Proliferative Capacity of Hematopoietic Stem Cells Deficient in Hoxb3 and Hoxb4

Several homeobox transcription factors, such as HOXB3 and HOXB4, have been implicated in regulation of hematopoiesis. In support of this, studies show that overexpression of HOXB4 strongly enhances hematopoietic stem cell regeneration. Here we find that mice deficient in both Hoxb3 and Hoxb4 have de...

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Detalhes bibliográficos
Main Authors: Björnsson, Jon Mar, Larsson, Nina, Brun, Ann C. M., Magnusson, Mattias, Andersson, Elisabet, Lundström, Patrik, Larsson, Jonas, Repetowska, Ewa, Ehinger, Mats, Humphries, R. Keith, Karlsson, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155209/
https://ncbi.nlm.nih.gov/pubmed/12748289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.11.3872-3883.2003
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