Rho Kinase, Myosin-II, and p42/44 MAPK Control Extracellular Matrix-mediated Apical Bile Canalicular Lumen Morphogenesis in HepG2 Cells

The molecular mechanisms that regulate multicellular architecture and the development of extended apical bile canalicular lumens in hepatocytes are poorly understood. Here, we show that hepatic HepG2 cells cultured on glass coverslips first develop intercellular apical lumens typically formed by a p...

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Main Authors: Herrema, Hilde, Czajkowska, Dominika, Théard, Delphine, van der Wouden, Johanna M., Kalicharan, Dharamdajal, Zolghadr, Behnam, Hoekstra, Dick, van IJzendoorn, Sven C.D.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2006
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1552049/
https://ncbi.nlm.nih.gov/pubmed/16687572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-01-0067
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