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Efficient Trafficking of MDR1/P-Glycoprotein to Apical Canalicular Plasma Membranes in HepG2 Cells Requires PKA-RIIα Anchoring and Glucosylceramide

In hepatocytes, cAMP/PKA activity stimulates the exocytic insertion of apical proteins and lipids and the biogenesis of bile canalicular plasma membranes. Here, we show that the displacement of PKA-RIIα from the Golgi apparatus severely delays the trafficking of the bile canalicular protein MDR1 (P-...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wojtal, Kacper A., de Vries, Erik, Hoekstra, Dick, van IJzendoorn, Sven C.D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Cell Biology 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1525225/
https://ncbi.nlm.nih.gov/pubmed/16723498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-03-0230
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