Kaposi's Sarcoma-Associated Herpesvirus-Induced Upregulation of the c-kit Proto-Oncogene, as Identified by Gene Expression Profiling, Is Essential for the Transformation of Endothelial Cells

Kaposi's sarcoma (KS), the most frequent malignancy afflicting AIDS patients, is characterized by spindle cell formation and vascularization. Infection with KS-associated herpesvirus (KSHV) is consistently observed in all forms of KS. Spindle cell formation can be replicated in vitro by infecti...

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Bibliographic Details
Main Authors: Moses, Ashlee V., Jarvis, Michael A., Raggo, Camilo, Bell, Yolanda C., Ruhl, Rebecca, Luukkonen, B. G. Mattias, Griffith, Diana J., Wait, Cecily L., Druker, Brian J., Heinrich, Michael C., Nelson, Jay A., Früh, Klaus
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Transformation and Oncogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC155158/
https://ncbi.nlm.nih.gov/pubmed/12134042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.16.8383-8399.2002
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